We are glad to announce that we recently released MetaSite7
- Overview: Our flagship product for predicting Cytochrome P450-mediated biotransformations just got a massive upgrade with the inclusion of combined prediction of phase I and phase II metabolism, site of metabolism heatmap visualization, metabolite pathways analysis, non-CYP metabolic reactions and much more. Furthermore, you can now alternate between command-line and GUI execution, such as importing objects and performing calculations via the command line, then browsing results in the GUI. In MetaSite7, these options are expanded to include all non-CYP Phase I enzymes, Phase II enzymes, or a combined CYP -Phase I – Phase II process.
- Recommendation level: Required
New Features
- New (nonCYP) Phase I enzymes
- Alcohol dehydrogenases
- Aldehyde dehydrogenases
- Aldo-keto reductases
- Carbonyl reductases
- Carboxylesterases
- Hydroxysteroid dehydrogenase
- Monoamine oxidases
- NAD(P)H quinone Oxidoreductase
- New Phase II enzymes
- Phosphatases
- Deaminases
- Carboxypeptidases
- Dipeptidases
- Glutathione S-transferases
- Methyltransferases
- Acetyltransferases
- Sulfotransferases
- Glucuronosyltransferase
- Combined Phase I & Phase II Prediction
- Sites of metabolism (SoM) prediction for phase I and phase II and an overall probability score indicating how likely a given compound is to be a substrate for a specific enzyme
- Innovative MetID Pathway Analysis
- REVENG (Reverse Engineering) function: from substrate/metabolite pairs to all possible predicted metabolic paths (since version 7.2 – CLI only)
- Isoform selectivity function
- A new, efficient and sophisticated algorithm
For more information, visit https://mass-analytica.com/products/metasite7/
You can download the new version at the product page: