LipostarMSI

LipostarMSI is a software for mass spectrometry imaging (MSI) lipidomics that supports both untargeted and targeted data analysis, distributed as desktop application. 

The workflow supported by LipostarMSI covers all the steps required for MSI data analysis: raw data processing, histological coregistration, manual drawing or importing of regions annotated by pathologists, image visualization, a variety of univariate and multivariate image and spectral analysis tools, co-localization analysis, and automated lipids, metabolites and drug metabolites annotation, including MS/MS-based identification. 

 

 

Data import

  • Vendor, Instrument & Acquisition neutral analysis  
  • Annotated ROI import 
  • Import of MS/MS spectra from LC-MS acquisitions 

Information

  • Peak detection and pre-processing 
  • Annotation and identification 
  • Biochemical Pathways

Omics

  • Targeted and untargeted omics analysis  
  • Lipids, metabolites and drug metabolites  

Image analysis

  • Denoise, contrast enhancement, normalization
  • Single and overlayed ion density images visualization
  • Coregistration with H&E

Data analysis

  • Segmentation 
  • Co-localization 
  • Principal Component Analysis 
  • Univariate and multivariate ROI analysis 

Automation

  • Background processing of computational intensive tasks
  • Optimized and parallelized algorithms
  • Automatic report generation

System requirements & Installation

  • System requirements
  • Installation instructions

Pharma –  Data Analysis –  Imaging

Articles:
Videos:

 

Life Sciences –  Imaging Metabolites

Articles:
Videos:
  • Oniro: for HTS rapifleX data analysis 
  • Pyxis suite: for multi-purpose MSI, including ion mobility MSI 
  • Lipostar: for LC-MS lipidomics  
  • MARS: for LC-MS metabolomics  
  • Action: for affinity measurement  
What exactly appears in the Data Analysis Matrix when I import the ROI into the ROI analysis module? [ROI analysis module] 

The Data analysis table represents a matrix in which lines are the ROIs and columns are peaks defined by m/z value. The values in the table are the Log base 2 values of the peak intensity and the number of MS/MS fragments associated with the peak, separated by a “/” symbol (Tutorial 3, pag 29). Note that the peak intensity is the average peak intensity within your ROI and it also depends on the normalization you may have selected when importing your ROI (Tutorial 3, pag 28). 

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